Offers funding for projects that address workforce gaps and economic challenges due to the impact of substance use disorder (SUD) in Appalachia. Funding to build or expand community support systems (also known as recovery ecosystems) that help Appalachians in SUD recovery obtain or maintain employment.

Supports counseling and assistance for low-income, first-generation and other priority adults (age 19 and older) who seek to enter or return to a postsecondary education.

Supports projects that create a vibrant economic future for the Delta region by expanding opportunities to recruit, train, and retain a diverse and local workforce; aligning workforce and economic development strategies; creating sustainable talent pipelines; building significant partnerships; investing in innovations to enhance workforce productivity.

Helps build systems to make homelessness rare, brief, and non-recurring with emphasis on helping people quickly regain permanent housing stability. Funds for rehab of buildings to use as emergency shelter (ES); services related to operating ES; street outreach for homeless people; homelessness prevention; rapid rehousing; Homeless Management Information System; and admin.

Provides financial assistance to address the continued unmet health needs in the Delta Region through cooperation among health care professionals, institutions of higher education, research institutions, and economic development entities.